Recombinant Human IL-20R alpha Fc Chimera Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

Recombinant Human IL-20R alpha Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized rhIL-20 Ra/Fc Chimera at 1 µg/mL (100 µL/well) can bind rhIL-26 with a linear range of 0.3-20 ng/mL.
Source
Mouse myeloma cell line, NS0-derived human IL-20 R alpha protein
Human IL-20 R alpha
(Val30 - Lys250)
Accession # Q9UHF4
DIEGRMD Human IgG1
(Pro100 - Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Val30
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
IL20RA
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Binding Activity
Theoretical MW
52 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
70-85 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-20R alpha Fc Chimera Protein, CF

  • class II cytokine receptor ZCYTOR7
  • CRF2-8
  • Cytokine receptor class-II member 8
  • Cytokine receptor family 2 member 8
  • FLJ40993
  • IL-20 R alpha
  • IL20R alpha
  • IL-20R alpha
  • IL-20R1
  • IL-20R1IL-20 receptor subunit alpha
  • IL20RA
  • IL-20Ra
  • IL-20R-alpha
  • interleukin 20 receptor, alpha
  • interleukin-20 receptor I
  • interleukin-20 receptor subunit alpha
  • zcytor7

Background

IL-20 receptor alpha (IL-20 R alpha ), also named IL-20 R1, CRF2-8, and ZCYTOR7, belongs to the class II cytokine receptor family, which includes 12 members. These receptors are characterized by the patterns of conserved amino acid (aa) residues in their extracellular domains, which are composed of tandem fibronectin type III domains (1). Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1).

The gene for human IL-20 R alpha is mapped to chromosome 6 and encodes a 553 aa glycoprotein with a 29 aa signal peptide, a 221 aa extracellular domain, a 24 aa transmembrane region and a 279 aa intracellular domain (2). IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland (1). The expression of IL-20 R alpha , together with that of IL-20 R beta , is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells (1, 2).

IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals (3, 4). IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26 (5). Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes (3 - 5).

  1. Kotenko, S.V. (2003) Cytokine & Growth Factor Reviews 13:223.
  2. Xie, M.H. et al. (2000) J. Biol. Chem. 275:31335.
  3. Dumoutier, L. et al. (2001) J. Immunol. 167:3534.
  4. Parrish-Novak, J. et al. (2002) J. Biol. Chem. 277:47517s.
  5. Sheikh. F. et al. (2004) J. Immunol. 172:2006.

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Bioinformatics

Gene Symbol IL20RA
Uniprot