Recombinant Human IL-1Rrp2/IL-1R6 Fc Chimera Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

Recombinant Human IL-1Rrp2/IL-1R6 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized recombinant human (rh) IL-1F5, rhIL-1F8, rhIL-1F6 or rhIL-1F9 at 1 µg/mL (100 µL/well) can bind rhIL-1Rrp2 Fc Chimera with a linear range of 0.15-5 µg/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human IL-1Rrp2/IL-1R6 protein
Human IL-1 R6
(Asp20-Tyr337)
Accession # Q9HB29
DIEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Asp20
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
IL1RL2
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Binding Activity
Theoretical MW
62.8 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
80 kDa, reducing conditions
Publications
Read Publication using
872-RP in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-1Rrp2/IL-1R6 Fc Chimera Protein, CF

  • IL-1 R6
  • IL-1 Rrp2
  • IL1RL2
  • IL-1RL2
  • IL1Rrp2
  • IL-1Rrp2
  • IL1RRP2IL1R-rp2Interleukin-1 receptor-related protein 2
  • interleukin 1 receptor-like 2
  • interleukin-1 receptor-like 2

Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1Rrp2 (IL-1 RL2/IL-1R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9) (1). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain (1). Human IL-1Rrp2 cDNA encodes a 561 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 318 aa extracellular domain. It shares 67% and 65% amino acid sequence identity with rat and mouse IL 1Rrp2, respectively. IL-1Rrp2 is expressed in lung epitheium, brain vasculature, kidney, testis, monocytes, skin-derived keratinocytes, fibroblasts and, to a lesser extent, endothelial cells (2, 3). IL-1Rrp2 has been shown to mediate the activation of the transcription factor NF kappa B by the IL-1 family ligands IL-1 F6, F8 or F9 (also known as IL-1 epsilon ), with IL-1RAcP as a cofactor (3, 4). Response to IL-1F9 is specifically antagonized by IL-1 F5 (also known as IL-1δ), an IL-1 family ligand that is most closely related to IL-1ra (3). IL-1Rrp2, IL-1 F5, and IL-1F9 are all up-regulated in lesional psoriasis skin, suggesting that the IL-1Rrp2 mediated signaling pathway may take part in local inflammatory responses (3).

 

  1. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
  2. Lovenberg, T. W. et al. (1996) J. Neuroimmunol. 70:113.
  3. Debets, R. et al. (2001) J. Immunol. 167:1440.
  4. Towne, J. E. et al. (2004) J. Biol. Chem. 279:13677.

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Publications for IL-1Rrp2/IL-1R6 (872-RP)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Binding Assay.


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Bioinformatics

Gene Symbol IL1RL2
Uniprot