RAMP2 Antibody

Western Blot: RAMP2 Antibody [NBP2-23672] - Analysis of RAMP2 using RAMP2 polyclonal antibody. Transfected 293T cells(1) and untransfected 293T cells (2) probed using RAMP2 antibody at 1:500.

Product Discontinued

RAMP2 Antibody Summary

• Immunogen: Within the range of amino acids 68-99 of human RAMP2 were used as the immunogen for this antibody.
• Predicted Species: Rhesus Macaque (100%), Chimpanzee (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RAMP2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:250-1: 1000

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 85% in Goat. IL-35 is a heterodimeric protein of p35/IL-12A and EBI3, with a molecular weight of approximately 78 kD. The recombinant IL-35 used for testing also contains a human Fc tag resulting in the approximately 100 kD size seen.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.1 ml crude whole Rabbit sera with 50% Glycerol
• Preservative: 0.025% Sodium Azide
• Purity: Unpurified

Alternate Names for RAMP2 Antibody

• calcitonin receptor-like receptor activity modifying protein 2
• Calcitonin-receptor-like receptor activity-modifying protein 2
• CRLR activity-modifying protein 2
• RAMP2
• receptor (calcitonin) activity modifying protein 2
• receptor (G protein-coupled) activity modifying protein 2
• receptor activity modifying protein 2
• receptor activity-modifying protein 2
• receptor-activity-modifying protein 2

Background

The protein encoded by the RAMP2 gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RAMP2
• Uniprot:
  • O60895(Human)