PPP2R4 Antibody (529245) [Alexa Fluor® 594]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 529245
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

PPP2R4 Antibody (529245) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human PPP2R4
  Glu14-Asn323
  Accession # Q15257
• Specificity: Detects endogenous human, mouse and rat PPP2R4 in Western blots.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PPP2R4 Antibody (529245) [Alexa Fluor® 594]

• EC 5.2.1.8
• MGC2184
• Phosphotyrosyl phosphatase activator
• PP2A phosphatase activator
• PP2A subunit B' isoform PR53
• PP2A
• PP2A, subunit B', PR53 isoform
• PPP2R4
• protein phosphatase 2A activator, regulatory subunit 4
• PTPA
• regulatory subunit B' (PR 53)
• serine/threonine-protein phosphatase 2A activator
• Serine/threonine-protein phosphatase 2A regulatory subunit 4
• Serine/threonine-protein phosphatase 2A regulatory subunit B'

Background

PPP2R4, also known as serine/threonine protein phosphatase 2A regulatory subunit B’, PR53 isoform, and PTPA, is a widely expressed member of the PTPA-type peptidyl prolyl isomerase family. Human PPP2R4 is 358 amino acids (aa) in length. Three splicing variants produce four isoforms for PPP2R4, and isoform 2 is the standard protein. Isoform 1, isoform 3 and isoform 4 have deletions corresponding to aa 73-107, 45-108, and 73-149 in isoform 2, respectively. Human PPP2R4 is 87% aa identical to mouse and rabbit PPP2R4. PPP2R4 reversibly stimulates the variable phosphotyrosyl phosphatase activity of the PP2A core heterodimer in the presence of ATP and Mg²⁺. It has been shown that p53 downregulates the expression of PPP2R4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q15257()