p57 Kip2 Antibody (KP10) [DyLight 650]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow, IHC, IHC-P
Clone
KP10
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Order Details

p57 Kip2 Antibody (KP10) [DyLight 650] Summary

Immunogen
Recombinant human p57Kip2 protein
Localization
Nuclear
Specificity
Recognizes a protein of 57kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CDKN1C
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for p57 Kip2 Antibody (KP10) [DyLight 650]

  • Beckwith-Wiedemann syndrome
  • BWS
  • cyclin-dependent kinase inhibitor 1C (p57, Kip2)
  • cyclin-dependent kinase inhibitor 1C
  • Cyclin-dependent kinase inhibitor p57
  • KIP2BWCR
  • p57
  • p57Kip2
  • WBS

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47764AF350
Alexa Fluor 405 NBP2-47764AF405
Alexa Fluor 488 NBP2-47764AF488
Alexa Fluor 532 NBP2-47764AF532
Alexa Fluor 594 NBP2-47764AF594
Alexa Fluor 647 NBP2-47764AF647
Alexa Fluor 700 NBP2-47764AF700
Alexa Fluor 750 NBP2-47764AF750
Allophycocyanin NBP2-47764APC
Biotin NBP2-47764B
DyLight 350 NBP2-47764UV
DyLight 405 NBP2-47764V
DyLight 488 NBP2-47764G
DyLight 550 NBP2-47764R
DyLight 594 NBP2-47764DL594
DyLight 650 NBP2-47764C
DyLight 680 NBP2-47764FR
DyLight 755 NBP2-47764IR
FITC NBP2-47764F
HRP NBP2-47764H
Janelia Fluor 549 NBP2-47764JF549
Janelia Fluor 646 NBP2-47764JF646
PE NBP2-47764PE
PerCP NBP2-47764PCP

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Bioinformatics Tool for p57 Kip2 Antibody (NBP2-47764C)

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Contact Information

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Calculators

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Bioinformatics

Gene Symbol CDKN1C