Recombinant Human p38 beta/MAPK11 Protein

Product Discontinued

Recombinant Human p38 beta/MAPK11 Protein Summary

• Description: Recombinant protein for Human p38 beta/MAPK11
  
  

  Source:Baculovirus (Sf9 insect cells)
  Amino Acid Sequence:(NM_002751)

• Source: Sf 9 (baculovirus)
• Protein/Peptide Type: Recombinant Protein
• Gene: MAPK11
• Purity: >90%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Application Notes: Specific activity: The specific activity of P38BETA was determined to be 123 nmol /min/mg as per activity assay protocol.
• Theoretical MW: 71 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 50mM Tris-HCl, pH 7.5, and 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
• Concentration: 0.1 mg/ml
• Purity: >90%, by SDS-PAGE

Alternate Names for Recombinant Human p38 beta/MAPK11 Protein

• EC 2.7.11
• EC 2.7.11.24
• MAP kinase 11
• MAP kinase p38 beta
• MAPK 11
• MAPK11
• mitogen-activated protein kinase 11
• Mitogen-activated protein kinase p38 beta
• mitogen-activated protein kinase p38-2
• MPK11
• p38 beta
• p38b
• p38beta
• P38BETA2
• PRKM11
• SAPK2B
• SAPK2p38-2P38B
• Stress-activated protein kinase 2
• stress-activated protein kinase-2
• stress-activated protein kinase-2b

Background

p38-Beta is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38-Beta is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: MAPK11