NQO-2 Antibody (1E3) Summary
Recombinant human NQO2 (1-231aa) purified from E. coli
Anti-human NQO2 mAb, clone 1E3, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NQO2 protein.
Protein G purified
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- Western Blot 1:500
- ELISA 1:100-1:2000
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:250 ~ 500. Recommended starting dilution is 1:500
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4) and 10% Glycerol
0.02% Sodium Azide
Protein G purified
Alternate Names for NQO-2 Antibody (1E3)
- EC 188.8.131.52
- NAD(P)H dehydrogenase, quinone 2
- NAD(P)H menadione oxidoreductase 2, dioxin-inducible
- NRH dehydrogenase [quinone] 2
- NRH:quinone oxidoreductase 2
- Quinone Reductase 2
- ribosyldihydronicotinamide dehydrogenase [quinone]
- ribosyldihydronicotinamide dehydrogenase
Quinone oxidoreductase (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic redaction of quinines and derivates.NQO2 is inhibited by flavones such as quercetin. Also benzo(a)pyrene is another known inhibitor of NQO2. Even though overlapping substrates specificities have been observed for NQO1 and NQO2, such as for CB1954 activation, significant differences exist in relative affinities for the various substrates.The detoxification role of NQO2 has not been found, and it has no known endogenous biological substrates. However, NQO1 plays an important role in the detoxification of various endogenous and exogenous quinones, including estrogen quinines. Also NQO2 has a melatonin-binding site, which may explain the anti-oxidant role of melatonin related with circadian rhythm.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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