Neurobeachin Antibody

Immunohistochemistry-Paraffin: Neurobeachin Antibody [NB100-55385] - Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Antibody at 5 ug/mL.

• Reactivity: Hu, Mu, Bv, Ca
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Neurobeachin Antibody Summary

• Description: Novus Biologicals Goat Neurobeachin Antibody (NB100-55385) is a polyclonal antibody validated for use in IHC, WB and ELISA. Anti-Neurobeachin Antibody: Cited in 2 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-DFNRWHYEHQNRY corresponding to C-Terminus according to NP_056493.3, NP_001191126.1.
• Epitope: DFNRWHYEHQNRY
• Specificity: This antibody is expected to recognise isoform 1 (NP_056493.3) and isoform 2 (NP_001191126.1).
• Predicted Species: Canine (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NBEA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 5 - 10 ug/mL
  • Immunohistochemistry-Paraffin 5 - 10 ug/mL
  • Peptide ELISA Detection limit 1:4000
  • Western Blot
• Application Notes: IHC-P: Human cerebral cortex shows textured cytoplasm staining in the neuronal cell bodies. Use in Western Blot reported in scientific literature (PMID:31680862).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Neurobeachin Antibody

• BCL8Blysosomal trafficking regulator 2
• EC 1.14.14.5
• EC 6.1.1.11
• FLJ10197
• KIAA1544
• Lysosomal-trafficking regulator 2
• LYST2
• neurobeachin
• Protein BCL8B

Background

Neurobeachin binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. It may anchor the kinase to cytoskeletal and/or organelle-associated proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Neurobeachin Antibody (NB100-55385)(2)

Publications using NB100-55385

• Cui J, Reed J, Crynen G et al. Proteomic Identification of Pathways Responsible for the Estradiol Therapeutic Window in AD Animal Models Front. Cell. Neurosci. 2019-10-15 [PMID: 31680862] (WB, Mouse)
• Wang X, Herberg FW, Laue MM et al. Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic. J Neurosci 2000-12-01 [PMID: 11102458]

Bioinformatics

• Gene Symbol: NBEA
• Entrez:
  • 26960(Human)
  • 26422(Mouse)
• Uniprot:
  • NP_056493(Human)