Nephronophthisis Antibody Pair

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Summary
Product Discontinued
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    • Catalog Number
      H00004867-PW1
    • Availability
      Product Discontinued

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Nephronophthisis Antibody Pair Summary

Description
Quality control test: Immunoprecipitation-Western Blot (IP-WB). This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.

  • Antibody pair for IP: rabbit polyclonal anti-NPHP1 (300 ul)
  • Antibody pair for WB: mouse polyclonal anti-NPHP1 (50 ul)
  • Clonality
    Polyclonal
    Gene
    NPHP1

    Applications/Dilutions

    Dilutions
    • Immunoprecipitation
    • Western Blot

    Packaging, Storage & Formulations

    Storage
    Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
    Buffer
    1x PBS, pH 7.4
    Preservative
    No Preservative

    Notes

    This product is produced by and distributed for Abnova, a company based in Taiwan.

    Alternate Names for Nephronophthisis Antibody Pair

    • FLJ97602
    • JBTS4NPH1Juvenile nephronophthisis 1 protein
    • nephrocystin 1
    • nephrocystin-1
    • nephronophthisis 1 (juvenile)
    • SLSN1

    Background

    Nephronophthisis encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

    Limitations

    This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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    Product General Protocols

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    Video Protocols

    WB Video Protocol

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    Bioinformatics

    Gene Symbol NPHP1