Myosin VIIa Antibody

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Western Blot: Myosin VIIa Antibody [NB120-3481] - Analysis of mouse testes tissue extract.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, Gp, PmSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Myosin VIIa Antibody Summary

Immunogen
Synthetic Peptide: S(16) G Q E F D V P I G A V V K L C(31)
Specificity
Detects Myosin VIIa from mouse tissues as well as recombinant protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MYO7A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 5 ug/ml
  • Immunohistochemistry
Application Notes
WB: Detects an approx. 220 kDa protein representing myosin VIIa from mouse testes preparations. Detects recombinant mouse myosin VIIa overexpressed in Sf9 insect cell lysate. Use in Immunohistochemistry reported in scientific literature (PMID:31895697).
Theoretical MW
254 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB120-3481 in the following applications:

  • IHC
    1 publication

Reactivity Notes

Guinea Pig

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Myosin VIIa Antibody

  • deafness, autosomal dominant 11
  • deafness, autosomal recessive 2
  • DFNA11
  • DFNB2
  • myosin VIIA
  • myosin-VIIa
  • MYOVIIA
  • MYU7A
  • USH1Bsevere))

Background

Myosin VIIa is a member of the myosin superfamily of actin-based motor proteins. Defects in the myosin VIIa gene are responsible for hearing impairment in shaker-1 (sh1) mice and causes Usher syndrome IB in humans. Usher syndrome associates congenital deafness, vestibular dysfunction, and retinitis pigmentosa and is the most common form of combined deafness and blindness. Structural features of myosin VIIa protein include an ATP binding N-terminal motor domain, a central region which possess five light-chain binding (IQ) motifs, and a C-terminal domain with three myosin tail homology (MyTH4) and talin-like homology regions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Myosin VIIa Antibody (NB120-3481)(2)

We have publications tested in 1 confirmed species: Guinea Pig.

We have publications tested in 1 application: IHC.


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IHC
(1)
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Filter By Species
Guinea Pig
(1)
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Bioinformatics

Gene Symbol MYO7A
Entrez
Uniprot