Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody

Immunohistochemistry-Paraffin: Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody [NLS1330] - Analysis of anti-CHRM2 antibody with human brain, neurons and glia at 4 ug/ml

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Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human Muscarinic Acetylcholine Receptor M2/CHRM2.
• Epitope: 3rd cytoplasmic domain of human
• Specificity: Human CHRM2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Rat (95%), Porcine (95%), Chimpanzee (100%), Orangutan (100%), Hamster (95%), Canine (95%), Primate (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CHRM2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4-8 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (95%), Mouse (89%), Sheep (89%), Bat (89%), Bovine (89%), Panda (89%), Rabbit (89%), Opossum (89%), Guinea (84%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody

• 7TM receptor
• cholinergic receptor, muscarinic 2
• CHRM2
• FLJ43243
• HM2
• mAChR M2
• MGC120006
• MGC120007
• muscarinic acetylcholine receptor M2
• muscarinic M2 receptor

Background

Muscarinic cholinergic receptor 2 is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CHRM2
• Entrez:
  • 1129(Human)