Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody

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Immunohistochemistry-Paraffin: Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody [NLS1330] - Analysis of anti-CHRM2 antibody with human brain, neurons and glia at 4 ug/ml

Product Details

Summary
Reactivity Hu, Rt, Po, Ca, Ha, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human CHRM2.
Epitope
3rd cytoplasmic domain of human
Specificity
Human CHRM2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Rat (95%), Porcine (95%), Hamster (95%), Canine (95%), Primate (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CHRM2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10 - 1:500

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (100%), Orangutan (100%), Gibbon (100%), Marmoset (95%), Elephant (95%), Mouse (89%), Sheep (89%), Bat (89%), Bovine (89%), Panda (89%), Rabbit (89%), Opossum (89%), Guinea Pig (84%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody

  • 7TM receptor
  • cholinergic receptor, muscarinic 2
  • CHRM2
  • FLJ43243
  • HM2
  • mAChR M2
  • MGC120006
  • MGC120007
  • muscarinic acetylcholine receptor M2
  • muscarinic M2 receptor

Background

Muscarinic cholinergic receptor 2 is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CHRM2
Entrez