Latrophilin 3/LPHN3 Antibody [Alexa Fluor® 594]

• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 594

Latrophilin 3/LPHN3 Antibody [Alexa Fluor® 594] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Latrophilin 3/LPHN3
  Phe20-Asn813
  Accession # NP_056051
• Specificity: Detects human Latrophilin 3/LPHN3 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

LPHN3 (Latrophilin 3; also CIRL3, CL3 and LEC3) is a predicted 162 kDa member of the LN-TM7 subfamily, GPCR 2 family of molecules. It appears to have a restricted expression pattern, being limited to the brain and adrenal gland. Although it is related to the black widow toxin receptor CIRL1, it does not serve as a toxin receptor. Mature human LPHN3 is a 7‑TM glycoprotein that is 1428 amino acids (aa) in length. Posttranslational processing cleaves the molecule into a 120 kDa ECD (aa 20‑841) and a noncovalently-associated 85 kDa 7-TM C-terminus (aa 842‑1447). The ECD is modular, and contains a SUEL-like lectin domain (aa 35‑124), an Olf region (aa 134‑393) and GPS domain (aa 802‑853). There are multiple splice events which, in the ECD, include a two aa substitution for aa 127‑131, a 13 aa insertion after Lys623, and a 39 aa substitution for aa 668‑1447. Over aa 20‑813, human LPHN3 shares 98% aa identity with mouse LPHN3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.