L1TD1 Antibody (901258) [Alexa Fluor® 532]

• Applications: WB, ICC/IF
• Clone: 901258
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

L1TD1 Antibody (901258) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human L1TD1
  Met1-Leu142
  Accession # Q5T7N2
• Specificity: Detects human L1TD1 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

L1TD1 (LINE-1 type transposase domain-containing protein 1; also known as ES cell-associated protein 11 and FLJ10884) is an RNA binding protein with a reported molecular weight of approximately 100 kDa.  It is 865 amino acids (aa) in length and shares 43% aa identity with mouse L1TD1.  L1TD1 is a marker for undifferentiated pluripotent stem cells.  Knock down of its expression in these cells has been shown to decrease the expression of critical pluripotency factors such as Nanog and Oct-3/4.  L1TD1 function in stem cells is likely regulated by its interaction with factors such as LIN-28 and is suggested to regulate RNA processing.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.