Recombinant Human Kallikrein 13 Protein

Product Discontinued

Recombinant Human Kallikrein 13 Protein Summary

• Description: A bioactive recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 17-277 of Human Kallikrein 13
  
  

  Source: E.coli

  Amino Acid Sequence: GGVSQESSKV LNTNGTSGFL PGGYTCFPHS QPWQAALLVQ GRLLCGGVLV HPKWVLTAAH CLKEGLKVYL GKHALGRVEA GEQVREVVHS IPHPEYRRSP THLNHDHDIM LLELQSPVQL TGYIQTLPLS HNNRLTPGTT CRVSGWGTTT SPQVNYPKTL QCANIQLRSD EECRQVYPGK ITDNMLCAGT KEGGKDSCEG DSGGPLVCNR TLYGIVSWGD FPCGQPDRPG VYTRVSRYVL WIRETIRKYE TQQQKWLKGP QHHHHHH

• Details of Functionality: Specific activity is > 8,000 pmol/min/ug. One unit will hydrolyze 1.0 pmole of BAEE to Na-Benzoyl-L-arginine per minute at pH8.0 at 25C.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: KLK13
• Purity: >90%, by SDS-PAGE
• Endotoxin Note: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • Functional
  • SDS-Page
• Theoretical MW: 29.7 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 10% glycerol
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: >90%, by SDS-PAGE

Alternate Names for Recombinant Human Kallikrein 13 Protein

• DKFZp586J1923
• EC 3.4.21
• EC 3.4.21.-
• Kallikrein 13
• Kallikrein-like protein 4
• kallikrein-related peptidase 13
• KLK13
• KLK-L4kallikrein-13
• KLKL4kallikrein-like gene 4

Background

KLK13, also known as Kallikrein 13, is a 30,6 kDa 277 amino acid protein, expressed in prostate, breast, testis and salivary gland, belongs to the peptidase S1 family, kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions including their implication in carcinogenesis based on growing evidence. Disease research is currently being studied with relation to KLK13 and ovarian cancer, breast cancer, noma, testicular cancer, lung adenocarcinoma, prostatitis, prostate cancer, and carcinoma. Interactions with KLK13 protein have been shown to involve SERPINF2, SERPINA1, and A2M in proteolysis and protein processing pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KLK13