IL-20R alpha Antibody (173714) [Alexa Fluor® 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
173714
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 405
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

IL-20R alpha Antibody (173714) [Alexa Fluor® 405] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL-20 R alpha
Val30-Lys250
Accession # Q9UHF4
Specificity
Detects human IL-20 R alpha in direct ELISAs and Western blots. In Western blots, approximately 5‑15% cross‑reactivity with recombinant human (rh) IFN-gamma R2, rhIL-10 R, rhIL-10 R beta, rhIL-20 R beta, and rhIL-22 BP is observed and no cross-reactivity with rhIFN-gamma RI, recombinant mouse IL‑20 R alpha, or rhIL‑22 R is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL20RA
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-20R alpha Antibody (173714) [Alexa Fluor® 405]

  • class II cytokine receptor ZCYTOR7
  • CRF2-8
  • Cytokine receptor class-II member 8
  • Cytokine receptor family 2 member 8
  • FLJ40993
  • IL-20 R alpha
  • IL20R alpha
  • IL-20R alpha
  • IL-20R1
  • IL-20R1IL-20 receptor subunit alpha
  • IL20RA
  • IL-20Ra
  • IL-20R-alpha
  • interleukin 20 receptor, alpha
  • interleukin-20 receptor I
  • interleukin-20 receptor subunit alpha
  • zcytor7

Background

IL-20 receptor alpha (IL-20 R alpha ), also named IL-20 R1, CRF2-8, and ZCYTOR7, belongs to the class II cytokine receptor family, which includes 12 members. These receptors are characterized by the patterns of conserved amino acid (aa) residues in their extracellular domains, which are composed of tandem fibronectin type III domains (1). Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1).

The gene for human IL-20 R alpha is mapped to chromosome 6 and encodes a 553 aa glycoprotein with a 29 aa signal peptide, a 221 aa extracellular domain, a 24 aa transmembrane region and a 279 aa intracellular domain (2). IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland (1). The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells (1, 2).

IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals (3, 4). IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26 (5). Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes (3‑5).

  1. Kotenko, S.V. (2003) Cytokine & Growth Factor Reviews 13:223.
  2. Xie, M.H. et al. (2000) J. Biol. Chem. 275:31335.
  3. Dumoutier, L. et al. (2001) J. Immunol. 167:3534.
  4. Parrish-Novak, J. et al. (2002) J. Biol. Chem. 277:47517s.
  5. Sheikh. F. et al. (2004) J. Immunol. 172:2006.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB11762U
Alexa Fluor 405 FAB11762V
Alexa Fluor 488 FAB11762G
Alexa Fluor 594 FAB11762T
Alexa Fluor 647 FAB11762R
Alexa Fluor 700 FAB11762N
Alexa Fluor 750 FAB11762S
Phycoerythrin FAB11762P

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Bioinformatics

Gene Symbol IL20RA
Uniprot