HPS3 Antibody

Images

 
Western Blot: HPS3 Antibody [NB100-1445] - (1ug/ml) staining of A431 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

HPS3 Antibody Summary

Immunogen
Peptide with sequence PYLLYCSRKKPLT corresponding to C-Terminus according to NP_115759.2.
Localization
Cytoplasmic
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
HPS3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 110 kDa band observed in A431 lysate (calculated MW of 114 kDa band according to NP_115759).
Positive Control
HPS3 Lysate (NBL1-11697)
A-431 Lysate (NB820-59461)
Publications
Read Publication using NB100-1445.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Porcine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for HPS3 Antibody

  • DKFZp686F0413
  • FLJ22704
  • Hermansky-Pudlak syndrome 3 protein
  • Hermansky-Pudlak syndrome 3
  • SUTAL

Background

HPS3 is involved in early stages of melanosome biogenesis and maturation. Defects in HPS3 are the cause of the cocoa (coa) mutant, and of Hermansky-Pudlak syndrome type 3 (HPS3). HPS3 is an autosomal recessive disorder, characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for HPS3 Antibody (NB100-1445)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for HPS3 Antibody (NB100-1445) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HPS3
Entrez
Uniprot