HM74A/PUMA-G/GPR109A/NIACR1 Antibody (245115) [FITC]

• Reactivity: Hu
• Applications: IHC
• Clone: 245115
• Clonality: Monoclonal
• Host: Rat
• Conjugate: FITC

HM74A/PUMA-G/GPR109A/NIACR1 Antibody (245115) [FITC] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: NS0 mouse myeloma cell line transfected with human HM74A/PUMA-G/GPR109A
  Met1-Pro363
  Accession # Q8TDS4
• Specificity: Detects human HM74A/PUMA-G/GPR109A in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product MAB27601. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for HM74A/PUMA-G/GPR109A/NIACR1 Antibody (245115) [FITC]

• GPR109A
• HCA2
• HCAR2
• HM74A
• hydroxycarboxylic acid receptor 2
• Niacr1
• Nicotinic Acid Receptor
• PUMAG

Background

Nicotinic acid receptors are a group of Gi/Go protein-coupled receptors that are currently divided into GPR81, GPR109Aand GPR109B subtypes. GPR109B receptors originated from a gene duplication of GPR109A and have > 95% homology. Allsubtypes are widely expressed throughout adipose tissue and are found at lower levels on macrophages, neutrophils,Langerhans cells and in the spleen. Nicotinic acid receptors are involved in the inhibition of lipolysis. The humangenes encoding these receptors are located on chromosome 12 (12q24.3)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.