Recombinant Human Hexim 1 Protein

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SDS-Page: HEXIM1 Protein [NBP1-37094] - HEXIM1, 44.8 kDa (396aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.5 mg/ml

Order Details

Recombinant Human Hexim 1 Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-359 of Human Hexim 1

Source: E.coli

Amino Acid Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAE PFLSEYQHQP QTSNCTGAAA VQEELNPERP PGAEERVPEE DSRWQSRAFP QLGGRPGPEG EGSLESQPPP LQTQACPESS CLREGEKGQN GDDSSAGGDF PPPAEVEPTP EAELLAQPCH DSEASKLGAP AAGGEEEWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRIRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYSKRAAAKS DDTSDDDFME EGGEEDGGSD GMGGDGSEFL QRDFSETYER YHTESLQNMS KQELIKEYLE LEKCLSRMED ENNRLRLESK RLGGDDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
HEXIM1
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
44.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human Hexim 1 Protein

  • Cardiac lineage protein 1
  • CLP1
  • CLP-1
  • CLP1hexamethylene-bis-acetamide-inducible transcript 1
  • EDG1HMBA-inducible
  • Estrogen down-regulated gene 1 protein
  • hexamethylene bis-acetamide inducible 1
  • Hexamethylene bis-acetamide-inducible protein 1
  • hexamthylene bis-acetamide inducible 1
  • Hexim 1
  • HEXIM1
  • HIS1
  • HIS1FLJ13562
  • HMBA-inducible
  • MAQ1
  • MAQ1hexamethylene bisacetamide-inducible protein
  • menage a quatre 1
  • Menage a quatre protein 1
  • protein HEXIM1

Background

HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This protein has been shown to form a protein-RNA complex composed of 7SK small nuclear RNA and positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1, and to inhibit the kinase activity of CDK9, thereby suppressing RNA polymerase II-dependent transcriptional elongation. Recombinant HEXIM1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol HEXIM1
Entrez