HERV Antibody (4F10)

Product Discontinued

HERV Antibody (4F10) Summary

• Immunogen: ERVWE1 (NP_055405, 116 a.a. ~ 216 a.a) partial recombinant protein with GST tag.DGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRTHTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINT
• Specificity: ERVWE1 (4F10)
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: ERVW-1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
• Application Notes: Antibody reactive against recombinant protein on ELISA. GST alone used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for HERV Antibody (4F10)

• endogenous retroviral family W, env(C7), member 1
• ENV
• envelope glycoprotein
• Envelope polyprotein gPr73
• enverin
• ENVW
• Env-W
• HERV-7q Envelope protein
• HERV7Q
• HERV-7q
• HERV-tryptophan envelope protein
• HERV-W Env glycoprotein
• HERV-W envelope protein
• HERV-W
• HERV-W_7q21.2 provirus ancestral Env polyprotein
• HERV-W{7q21.1} provirus ancestral Env polyprotein
• HERVWENV
• HERV-W-ENV
• HERVWenvelope protein
• human endogenous retrovirus W envC7-1 envelope protein
• syncytin A
• Syncytin
• syncytin-1

Background

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HERV Antibody (H00030816-M06)(3)

Publications using H00030816-M06

• Fitzgerald W, Gomez-Lopez N, Erez O et al. Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors. Am J Reprod Immunol 2018-03-27 [PMID: 29726582]
• Ruebner M, Langbein M, Strissel PL et al. Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPAR?/RXR? in placentogenesis. J Cell Biochem 2012-07-01 [PMID: 22573555]
• Ruebner M, Strissel PL, Langbein M et al. Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes. J Mol Med 2010-07-28 [PMID: 20664994]

Bioinformatics

• Gene Symbol: ERVW-1
• Entrez:
  • 30816(Human)
• OMIM:
  • 604659(Human)
• Uniprot:
  • NP_055405(Human)