GPR88 Antibody (1039818) [Alexa Fluor® 488]

• Reactivity: Hu
• Clone: 1039818
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

GPR88 Antibody (1039818) [Alexa Fluor® 488] Summary

• Specificity: Detects human GPR88 in ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GPR88 Antibody (1039818) [Alexa Fluor® 488]

• G protein coupled receptor 88
• G protein-coupled receptor 88
• GPR88
• G-protein coupled receptor 88
• probable G-protein coupled receptor 88
• STRG
• Striatum-specific G-protein coupled receptor

Background

GPR88 is an orphan receptor that probably belongs to the G-protein coupled receptor family.  Ligands for this receptor still largely remain unknown but agonists have been discovered.  It is a brain-specific receptor with almost exclusive expression in the striatum, being preferentially localized in medium spiny neurons.  Because of its expression, GPR88 is emerging as a drug target for CNS disorders such as schizophrenia, Parkinson's disease, anxiety, and addiction. Gpr88 KO mice data suggests that striatal GPR88 receptors influence activity in a range of procedures integrated by prefrontal, orbitofrontal and anterior cingulate cortico-striatal-thalamic loops leading to altered cognitive, motivational and reward evaluation processes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.