GPR37 Antibody

Images

 
Immunohistochemistry-Paraffin: GPR37 Antibody [NLS129] - Anti-PAEL Receptor / GPR37 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: GPR37 Antibody [NLS129] - Analysis of anti-GPR37 antibody with human brain, neurons and glia at 1 ug/ml.
Immunohistochemistry-Paraffin: GPR37 Antibody [NLS129] - Anti-PAEL Receptor / GPR37 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: GPR37 Antibody [NLS129] - Anti-PAEL Receptor / GPR37 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more

Product Details

Summary
Reactivity Hu, Rt, Ha, Mk, Pm, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

GPR37 Antibody Summary

Immunogen
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.
Localization
Cell Membrane
Specificity
Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Rat (95%), Hamster (90%), Primate (95%), Monkey (95%), Rabbit (90%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GPR37
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Marmoset (95%), Elephant (95%), Mouse (85%), Equine (85%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GPR37 Antibody

  • EDNRBL
  • Endothelin B receptor-like protein 1
  • ETBR-LP-1
  • G protein-coupled receptor 37 (endothelin receptor type B-like)
  • GPR37
  • hET(B)R-LP
  • PAELR
  • PAELRETBR-LP-1
  • Parkin-associated endothelin receptor-like receptor
  • probable G-protein coupled receptor 37

Background

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GPR37
Entrez
Uniprot