GPR17 Antibody

Images

 
Western Blot: GPR17 Antibody [NBP1-51988] - Staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot: GPR17 Antibody [NBP1-51988] - NBP1-51988 (0.1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

GPR17 Antibody Summary

Immunogen
Peptide with sequence C-EGKTNESSLSAKSE corresponding to C-Terminus according to NP_005282.1.
Epitope
C-EGKTNESSLSAKSE
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
GPR17
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Peptide ELISA Detection limit 1:1000
Application Notes
WB: Approx. 45 kDa band observed in human brain (cerebellum), and in mouse and rat brain lysates (calculated MW of 41.0 kDa band according to human NP_005282.1 and 37.9 kDa band according to rat NP_001065245.1).
Publications
Read Publication using NBP1-51988.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GPR17 Antibody

  • DKFZp686M18273
  • G protein-coupled receptor 17
  • GPR17
  • G-protein coupled receptor 17
  • P2Y-like Receptor
  • R12
  • UDP/CysLT Receptor
  • uracil nucleotide/cysteinyl leukotriene receptor

Background

GPR17, a former orphan G-coupled protein is specifically activated by P2Y and CysLT endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In both rats and humans GPR17 expressed in the organs which suffer ischemic damage, like the brain, heart and kidneys. Studies by Ciana, et. al. have shown that inhibition of GPR17 reduces ischemic damage in a rat focal ischemia model. These results suggest GPR17 is the common molecular target mediating brain damage by nucleotides and CysLTs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GPR17 Antibody (NBP1-51988)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GPR17
Entrez
Uniprot