GFR alpha-like Antibody [Alexa Fluor® 647]

• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 647

GFR alpha-like Antibody [Alexa Fluor® 647] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse GFRα-like isoform A
  Gln20-Gly349
  Accession # Q6SJE0
• Specificity: Detects mouse GFR alpha -like in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GFR alpha-like Antibody [Alexa Fluor® 647]

• bA360D14.1
• C6orf144
• GDNF family receptor alpha-like
• GFR alpha like
• GFR alpha-like
• GFRAL
• GRAL
• IVFI9356
• UNQ9356

Background

GFR alpha -like (GDNF receptor-alpha-like) is a predicted 26 and 44 kDa glycoprotein (1) and distant member of the GDNFR family of proteins. It is expressed on both fetal and adult neurons of the CNS, and would appear to function as an anti-apoptotic molecule during neuronal stress. Mature mouse GFR alpha -like is a 374 amino acid (aa) type I transmembrane protein. It contains a 330 aa extracellular region that shows a Gas1 domain (aa 131‑210), and a 23 aa cytoplasmic tail. There is one splice variant that is likely soluble and shows a four aa substitution for aa 235‑393. Over aa 20‑349, mouse GFR alpha -like shares 72% aa identity with human GFR alpha -like.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q6SJE0(Rat)