Fibrinogen Antibody (40F11) - BSA Free

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 40F11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

Fibrinogen Antibody (40F11) - BSA Free Summary

• Immunogen: Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with Fibrin degradation products.
• Localization: Secreted
• Specificity: Human fibrinogen and fibrin degradation products.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: FGA
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunoassay
  • Sandwich ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: Recommended pair for sandwich immunoassay (capture - detection): NB120-10068 - NB120-10066.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for Fibrinogen Antibody (40F11) - BSA Free

• Factor I
• Fib2
• fibrinogen alpha chain
• Fibrinogen
• fibrinogen, A alpha polypeptide
• MGC119422
• MGC119423
• MGC119425

Background

Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Fibrinogen Antibody (NB120-10068)(2)

Publications using NB120-10068

• Bellier JP, Rom�n Viera AM, Christiano C et al. Identification of fibrinogen as a plasma protein binding partner for lecanemab biosimilar IgG. Annals of clinical and translational neurology 2024-10-30 [PMID: 39476320]
• Coverley D, Higgins G, West D et al. A quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma. Clin. Biochem. 2016-11-17 [PMID: 27867087] (WB)

Bioinformatics

• Gene Symbol: FGA
• Entrez:
  • 2243(Human)