Exostosin-like 2/EXTL2 Antibody (339509) [Allophycocyanin]

• Reactivity: Mu
• Applications: WB
• Clone: 339509
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Allophycocyanin

Exostosin-like 2/EXTL2 Antibody (339509) [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Exostosin-like 2/EXTL2
  Asn43-Met330
  Accession # Q9ES89
• Specificity: Detects mouse Exostosin-like 2/EXTL2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse EXTL1, recombinant human (rh) Exostosin-like 2/EXTL2, or rhEXTL3 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: EXTL2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for Exostosin-like 2/EXTL2 Antibody (339509) [Allophycocyanin]

• Alpha-1,4-N-acetylhexosaminyltransferase EXTL2
• alpha-1,4-N-acteylhexosaminyltransferase
• Alpha-GalNAcT EXTL2
• EC 2.4.1.223
• exostoses (multiple)-like 2
• Exostosin like 2
• Exostosin-like 2
• EXTL2
• EXTR2
• EXT-related protein 2
• Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
• processed exostosin-like 2

Background

Exostosin-like 2, or EXTL2 can be found in the extracellular region of the endoplasmic reticulum and is integral to the membrane. Belonging to the glycosyltransferase 47 family, EXTL2 encodes 4-N-acetylhexosamynyltransferase and transfers N-acetylglucosamine to the glycosaminoglycan (GAG) protein linkage region. More specifically, EXTL2 is critical for the synthesis of heparin/heparan sulfate, and the lack of EXTL2 can cause GAG overproduction. Biological processes associated with EXTL2 include the N-acetylglucosamine metabolic process, heparan sulfate proteoglycan biosynthetic process and UDP-N-acetylgalactosamine metabolic process. Known diseases for EXTL2 include Exostosis and hereditary multiple exostoses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EXTL2