Exostosin-like 2/EXTL2 Products

Description

Exostosin-like 2, or EXTL2 can be found in the extracellular region of the endoplasmic reticulum and is integral to the membrane. Belonging to the glycosyltransferase 47 family, EXTL2 encodes 4-N-acetylhexosamynyltransferase and transfers N-acetylglucosamine to the glycosaminoglycan (GAG) protein linkage region. More specifically, EXTL2 is critical for the synthesis of heparin/heparan sulfate, and the lack of EXTL2 can cause GAG overproduction. Biological processes associated with EXTL2 include the N-acetylglucosamine metabolic process, heparan sulfate proteoglycan biosynthetic process and UDP-N-acetylgalactosamine metabolic process. Known diseases for EXTL2 include Exostosis and hereditary multiple exostoses.

Bioinformatics

Entrez	2135 Human
Uniprot	AAH36015 Human AAH36015.1 Human NM_001439 Human NP_001028197 Human NP_001028197.1 Human Q9UBQ6 Human
Product By Gene ID	2135
Alternate Names	Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 alpha-1,4-N-acteylhexosaminyltransferase Alpha-GalNAcT EXTL2 EC 2.4.1.223 exostoses (multiple)-like 2 exostosin-like 2 EXTR2 EXT-related protein 2 Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase processed exostosin-like 2

Research Areas for Exostosin-like 2/EXTL2

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Stem Cell Markers