EMR3 Antibody

Immunohistochemistry-Paraffin: EMR3 Antibody [NLS1669] - Anti-EMR3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: EMR3 Antibody [NLS1669] - Analysis of anti-EMR3 antibody with spleen, lymphocytes at 21 ug/ ml.

Immunohistochemistry-Paraffin: EMR3 Antibody [NLS1669] - Analysis of anti-EMR3 antibody with human lymph node, Hodgkins lymphoma.

Product Discontinued

EMR3 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EMR3.
• Specificity: Human EMR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADGRE3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 21 - 42 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Orangutan (100%), Gibbon (100%), Bovine (89%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for EMR3 Antibody

• egf-like module containing, mucin-like, hormone receptor-like 3
• EGF-like module receptor 3
• EGF-like module-containing mucin-like hormone receptor-like 3
• egf-like module-containing mucin-like receptor 3
• EMR3

Background

EMR3 is an Orphan-B GPCR with an unknown ligand. Two variants are produced by alternative splicing. One form encodes a 652-amino acid GPCR consisting of two EGF-like domains and a mucin stalk, while the other is a truncated soluble form containing only two EGF-like domains. EMR3 and EMR2 share a high degree of sequence identity in the transmembrane domains. EMR3 has been reported to be expressed in neutrophils, monocytes, and macrophages. ESTs have been isolated from liver/spleen and mixed libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADGRE3
• Entrez:
  • 84658(Human)