DUSP12 Antibody

Product Discontinued

DUSP12 Antibody Summary

• Immunogen: The immunogen for this antibody was a sequence from 1a.a. to 340a.a. from DUSP12(a 340a.a. long protein)
• Localization: Nuclear
• Specificity: DUSP12
• Clonality: Polyclonal
• Host: Chicken
• Gene: DUSP12
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
• Control:

  DUSP12 Overexpression Lysate

Reactivity Notes

This antibody is reactive against Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for DUSP12 Antibody

• dual specificity phosphatase 12
• dual specificity protein phosphatase 12
• Dual specificity tyrosine phosphatase YVH1
• DUSP1YVH1 protein-tyrosine phosphatase ortholog
• EC 3.1.3.48
• serine/threonine specific protein phosphatase
• TDSP4
• YVH1EC 3.1.3.16

Background

DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. DUSP12 belongs to the protein tyrosine phosphatase family. Non receptor class dual specificity subfamily.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DUSP12
• Entrez:
  • 11266(Human)
• Uniprot:
  • Q5VXA8(Human)