DOG1/TMEM16A Antibody (DOG1.1)

Images

 
Immunohistochemistry-Paraffin: DOG1/TMEM16A Antibody (DOG1.1) [NBP1-49559] - FFPE gastrointestinal stromal tumor stained with D0G1 antibody.
Immunohistochemistry-Paraffin: DOG1/TMEM16A Antibody (DOG1.1) [NBP1-49559] - Gastrointestinal stromal tumor tissue.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-Fr, IHC-P
Clone
DOG1.1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
Predilute

Order Details

DOG1/TMEM16A Antibody (DOG1.1) Summary

Immunogen
A synthetic peptide of human DOG1/TMEM16A protein
Localization
Cytoplasmic and membrane
Specificity
DOG1/TMEM16A is expressed ubiquitously in gastrointestinal stromal tumors irrespective of c-kit or PDGFR alpha mutation status. Reactivity for DOG1/TMEM16A may aid in the diagnosis of gastrointestinal stromal tumors, including PDGFRA mutants that fail to express c-kit antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the c-kit tyrosine kinase.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
ANO1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
For IHC:. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10mM EDTA buffer, pH 8.0 prior to immunostaining.
Publications
Read Publications using NBP1-49559.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Saline & Casein Solution
Preservative
Sodium Azide and Proclin 300
Concentration
Predilute
Purity
Protein A or G purified

Notes

Positive Control: Gastrointestinal stromal tumor tissue Staining Protocol: We suggest an incubation period of 30-60 minutes at room temperature. Optimal incubation conditions should be determined by the user based upon the fixation conditions and staining system employed. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10mM EDTA buffer, pH 8.0 prior to immunostaining. This product has a prediluted size available. If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution). Use recommended dilution for the concentrated vials only.

Alternate Names for DOG1/TMEM16A Antibody (DOG1.1)

  • ANO1
  • anoctamin 1
  • DOG1
  • ORAOV2
  • TAOS2
  • TMEM16A

Background

TMEM16A belongs to the anoctamin family. TMEM16A acts as a calcium-activated chloride channel. It is required for normal tracheal development.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for DOG1/TMEM16A Antibody (NBP1-49559)(2)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ANO1
Entrez
Uniprot