CRLR Synthetic Peptide

Product Discontinued

CRLR Synthetic Peptide Summary

• Description: Synthetic rat calcitonin gene related peptide.
  
  

  Source:Synthetic

  Amino Acid Sequence:H2N-SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2

• Preparation Method: Solid phase synthesis
• Source: Synthetic
• Protein/Peptide Type: Synthetic Peptide
• Gene: CALCRL
• Purity: >95%, by HPLC

Applications/Dilutions

• Dilutions:
  • ELISA
• Theoretical MW: 3.8 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from eluent TFA in ACN/H2O
• Concentration: 1 mg/ml
• Purity: >95%, by HPLC
• Reconstitution Instructions: Reconstitute in sterile distilled water.

Alternate Names for CRLR Synthetic Peptide

• calcitonin gene-related peptide type 1 receptor
• calcitonin receptor-like
• CALCRL
• CGRP type 1 receptor
• CGRPR
• CGRPRCRLRCalcitonin receptor-like receptor
• CRLR

Background

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: CALCRL