CrkRS Antibody

Product Discontinued

CrkRS Antibody Summary

• Immunogen: The immunogen for this antibody is a synthetic 19 amino acid peptide from C-terminus of human CDK12/CrkRS.
• Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except POMT1 (37%).
• Predicted Species: Porcine (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDK12
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4-5 ug/ml

Reactivity Notes

Expected species cross reactivity based on sequence homology: Elephant, Gorilla, Gibbon, Marmoset, Panda (100%); Bovine, Horse, Opossum (89%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for CrkRS Antibody

• Cdc2-related kinase, arginine/serine-richCrkRS
• Cell division cycle 2-related protein kinase 7
• Cell division protein kinase 12
• CRK7CDC2-related protein kinase 7
• CRKR
• CRKRS
• cyclin-dependent kinase 12
• EC 2.7.11
• EC 2.7.11.23
• hCDK12
• KIAA0904EC 2.7.11.22

Background

CrkRS (Cdc2-related kinase, arginine/serine-rich) is a Cdc-2 related kinase that contains an arginine- and serine-rich (SR) domain and has recently been reported to interact with cyclin L1 and L2. Since it has been discovered that CrkRs pairs with a cyclin partner, it has also been given the name CDK12. CrkRs localizes to nuclear speckles and immunoprecipitates with RNA polymerse II and the SF2/ASF splicing factor and is proposed to play a role in the regulation of alternative splicing. Alternate names for CrkRS include cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, CRKRS, CRK7, and KIAA0904.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDK12
• Uniprot:
  • Q9NYV4(Human)