COPB2 Antibody

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Western Blot: COPB2 Antibody [NB120-2915] - Analysis of Beta-COP from PC-12 cell lysates.

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, Flow, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

COPB2 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues K(494) V L A A Q E T H E G V T E D G I E(511) of rat beta-COP.
Specificity
Detects coatomer-protein I beta (COP I beta).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
COPB2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 3-5 ug/10^6 cells
  • Immunocytochemistry/Immunofluorescence 2 ug/ml
  • Western Blot 2 ug/ml
Application Notes
ICC/IF usage was reported in scientific literature (PMID: 11056392). WB: Detects an approx. 115 kDa protein representing COP I beta from PC-12 cell extract.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 23845592).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for COPB2 Antibody

  • beta prime subunit
  • Beta'-coat protein
  • Beta'-COP
  • betaprime-COP
  • coatomer protein complex, subunit beta 2 (beta prime)
  • coatomer subunit beta'
  • p102

Background

Coatomer proteins are involved in regulating transport between the endoplasmic reticulum (ER) and the Golgi complex and in intra-Golgi transport. There exist two coatomer-protein mechanisms (COP I and COP I) and although they have mechanistic parallels, they are molecularly distinct. The COP I coat is comprised of seven subunits (alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP) in a complex called coatomer. Assembly of the coatomer (COP I) onto non-clathrin coated vesicles is regulated by ADP-ribosylation factor (ARF). Vesicle formation, budding, fusion, and disassembly is dependent on GDP-GTP exchange, COP I, and ARF. COP I has been shown to facilitate retrograde intracellular transport from the ER to the Golgi complex. By contrast, COP II facilitates anterograde transport between these subcellular organelles. COP II has been shown to be independently and selectively recruited to the ER relative to COP I subunits.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol COPB2
Entrez