CEP290 Antibody

Images

 
Immunofluorescence: CEP290 Antibody [NBP1-52132] - Overnight staining of cell lines OPCT-1 (A) and MDA468 (fB) with Alexa Fluor 568 (red) and nuclear counter staining with DAPI (blue), provided by Dr S, McArdle, and ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC-P, PEP-ELISA, IF
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated

Order Details

CEP290 Antibody Summary

Immunogen
Peptide with sequence C-RNSKHLKQQQYRAEN corresponding to internal region according to NP_079390.3.
Epitope
C-RNSKHLKQQQYRAEN
Specificity
Despite similarity of the immunizing peptide with the mouse protein, this antibody was demonstrated to weak for mouse Cep290.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CEP290
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
  • Peptide ELISA Detection limit 1:128000
  • Immunofluorescence
Application Notes
ICC: Formaldehyde-fixed cell lines derived from prostate cancer and from breast cancer show typical centrosomal staining. WB: Preliminary experiments gave an approx. 80 kDa band in human kidney, testis, and HeLa lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 290 kDa band according to NP_079390.3. The 80 kDa band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-52132.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for CEP290 Antibody

  • BBS14Bardet-Biedl syndrome 14 protein
  • Cancer/testis antigen 87
  • centrosomal protein 290kDa
  • Cep290
  • CT87JBTS6
  • FLJ13615
  • JBTS5CTCL tumor antigen se2-2
  • KIAA0373FLJ21979
  • LCA10monoclonal 3H11 antigen
  • MKS4
  • Nephrocystin-6
  • NPHP6centrosomal protein of 290 kDa
  • POC3 centriolar protein homolog
  • POC3
  • prostate cancer antigen T21
  • rd16,3H11AG
  • SLSN6nephrocytsin-6,3H11Ag
  • Tumor antigen se2-2

Background

CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CEP290 Antibody (NBP1-52132)(1)

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Secondary Antibodies

 

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Blogs on CEP290.

LAMP2: Protector of the lysosome
LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...  Read full blog post.

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Bioinformatics

Gene Symbol CEP290
Entrez
Uniprot