CBX4 Antibody

Western Blot: CBX4 Antibody [H00008535-B01P] - Analysis of CBX4 expression in human placenta.

Western Blot: CBX4 Antibody [H00008535-B01P] - Analysis of CBX4 expression in transfected 293T cell line by CBX4 polyclonal antibody. Lane 1: CBX4 transfected lysate(31.9 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

CBX4 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: CBX4 (AAH14967.1, 1 a.a. - 290 a.a.) full-length human protein. MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: CBX4
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: It has been used for WB and Functional.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CBX4 Antibody

• chromobox homolog 4 (Drosophila Pc class)
• chromobox homolog 4
• Chromobox protein homolog 4
• Drosophila)
• E3 SUMO-protein ligase CBX4
• hPC2
• NS5ATP1-binding protein 16
• Pc class 2 homolog
• PC2
• Polycomb 2 homolog

Background

PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CBX4
• Uniprot:
  • AAH14967.1(Human)