Calsyntenin-1 Antibody

Western Blot: Calsyntenin-1 Antibody [H00022883-D01P] - Analysis of CLSTN1 expression in human kidney.

Western Blot: Calsyntenin-1 Antibody [H00022883-D01P] - Analysis of CLSTN1 expression in transfected 293T cell line by CLSTN1 polyclonal antibody.Lane 1: CLSTN1 transfected lysate(108.70 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

Calsyntenin-1 Antibody Summary

• Immunogen: CLSTN1 (AAH33902.1, 1 a.a. - 971 a.a.) full-length human protein. MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYADGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVACAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHRSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVHSTATVVIVVCVSSLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CLSTN1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is useful for Western Blot

Reactivity Notes

This product is reactive against Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Calsyntenin-1 Antibody

• alcadein alpha 1
• Alcadein-alpha
• ALC-ALPHA
• alcalpha1
• alcalpha2
• Alzheimer-related cadherin-like protein
• cadherin-related family member 12
• calsyntenin 1
• Calsyntenin1
• Calsyntenin-1
• CDHR12
• CLSTN1
• CS1
• CSTN1
• FLJ32258
• KIAA0911alcadein-alpha
• Non-classical cadherin XB31alpha
• non-classical cadherin XB31alpha1
• PIK3CD
• XB31alpha

Background

CLSTN1 (calsyntenin 1) is mainly expressed in brain tissues and to a lesser degree in heart, skeletal muscle and the placenta. It accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques. The protein induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. It is involved in complex formation with APBA2 and APP, stabilizing APP metabolism and enhancing APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. It may also modulate calcium-mediated postsynaptic signals.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLSTN1
• Uniprot:
  • AAH33902.1(Human)