Bestrophin 3 Antibody

Immunohistochemistry-Paraffin: Bestrophin 3 Antibody [NB110-55617] - Analysis of anti-BEST3 antibody with human skeletal muscle.

Product Discontinued

Bestrophin 3 Antibody Summary

• Immunogen: Synthetic 20 amino acid peptide from internal region of human Bestrophin 3.
• Epitope: near N-terminal domain of human
• Specificity: Human BEST3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Porcine (90%), Bovine (90%), Hamster (90%), Bat (95%), Monkey (100%), Primate (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BEST3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2.5 - 5 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (95%), Canine (85%), Rabbit (85%), Mouse (80%), Rat (80%), Equine (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Bestrophin 3 Antibody

• bestrophin 3
• bestrophin-3
• MGC13168
• MGC40411
• vitelliform macular dystrophy 2-like 3
• VMD2L3Vitelliform macular dystrophy 2-like protein 3

Background

VMD2L3, a bestrophin, is an anion channel. The VMD2 gene underlying vitelliform macular dystrophy and the 3 VMD2-like genes, VMD2L1, VMD2L2, and VMD2L3, encode transmembrane (TM) spanning proteins that share a homology region with a high content of aromatic residues including an invariant arginine (R), phenylalanine (F), and proline (P) motif. VMD2 and the 3 VMD2-related genes share a conserved gene structure with almost identical sizes of the 8 RFP-TM domain encoding exons and highly conserved positions of their corresponding exon-intron boundaries. Each of the 4 paralogous genes contains a unique 3-prime end of variable length without significant homology to known proteins or motifs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BEST3
• Entrez:
  • 144453(Human)