HMGB1/HMG-1 Products

Description

HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. HMGB1 and HMGB2 (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain a N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of HMGB1 and HMGB2 contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. HMGB1 and HMGB2 may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.

Bioinformatics

Entrez	15289 Mouse 25459 Rat 3146 Human
Uniprot	AAH03378 Human AAH03378.1 Human NM_002128 Human NP_002119 Human NP_002119.1 Human P09429 Human P63158 Mouse P63159 Rat
Product By Gene ID	3146
Alternate Names	Amphoterin high mobility group box 1 High mobility group protein 1 high mobility group protein B1 high-mobility group (nonhistone chromosomal) protein 1 high-mobility group box 1 HMG-1 HMG1DKFZp686A04236 HMG3 SBP-1 Sulfoglucuronyl carbohydrate binding protein

Research Areas for HMGB1/HMG-1

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Chromatin Research
Histones and Modified Histones
Neuroscience
Transcription Factors and Regulators

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