Tumor

Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survivin is acetylated at lysine residue 129, thereby affecting its subsequent subcellular localization.

Novus' Pyruvate Kinase M2 antibody (cat # NBP1-48308) has received some glowing product reviews and customer feedback lately. One satisfied customer wrote, "The best thing about this antibody is that it works well for immunofluorescence staining of frozen sections of rat glioblastoma tumor samples... [The staining] is exactly what we expected. This result further confirms that the antibody is specific for PKM2, and not PKM1."

C-Myc is a widely expressed transcription factor, regulating cellular differentiation, proliferation, cell cycle progression and pro-apoptotic gene expression. The c-Myc antibody is widely used in cancer research, as a number of human tumors have been attributed to altered c-Myc expression.

Laminin is one of a large number of proteins expressed on the basal laminar of the ECM (extracellular matrix). The laminin antibody database covers several proteins, which interact with integrins and other receptor proteins to support cellular differentiation, morphology, migration, cell survival and the maintenance of tissue phenotypes. Laminin antibody studies have played a key role in research into angiogenesis and tumor development.

In rodents, MAP1LC3 (Microtubule-associated protein 1 light chain 3) is expressed in the renal visceral epithelial cells, or podocytes. LC3 antibody analysis has shown the protein accumulates in its membrane-bound form, LC3II, following conversion from LC3I.

MMP2 antibodies have proven to be important tools for cancer research and extracellular matrix studies. Novus Biologicals offers an excellent MMP2 antibody (Catalog Number NB200-114) for Western blot, immunoprecipitation, ELISA, and immunohistochemical/immunofluorescence staining in human, mouse and rat samples. Originally developed in 2005, this MMP-2 clone (8B4) has been thoroughly characterized and cited in a growing number of published journal articles.

Tumor Necrosis Factor alpha (TNFa) is a cytokine protein that plays an essential role in inducing the systemic inflammatory response, being expressed in tissues throughout the body. In autoimmune diseases such as rheumatoid arthritis and psoriasis, TNF alpha causes negative clinical effects. These can be controlled by inhibitory TNF antibody drugs, a number of which are now on the market. We at Novus Biologicals have an extensive range of TNF alpha antibodies.

Our antibody catalog includes an extensive range of Rad51 antibody reagents. Encoded by the RAD51 gene, the Rad51 protein plays a vital role in DNA repair, interacting with several other proteins, including BRCA1 and BRCA2, to effect homologous recombination at double-strand breaks.

The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in disease research, as hypoxia is known to contribute to many diseases including cancer, pulmonary hypertension and congenital heart disease. We at Novus Biologicals are one of the leading antibody suppliers of HIF-1 products.

Nestin is a large class Vl intermediate filament protein predominantly expressed in the neuroepithelial stem cells of the embryonic central nervous system, although recent nestin antibody studies have shown it expressed in other cell types, including vascular endothelial cells. The first monoclonal nestin antibody was developed by Hockfield and McKay in 1985.