Apoptosis

The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.

There are three human isoforms of the AKT gene, which plays a key role in several signalling pathways.

C-Myc is a widely expressed transcription factor, regulating cellular differentiation, proliferation, cell cycle progression and pro-apoptotic gene expression. The c-Myc antibody is widely used in cancer research, as a number of human tumors have been attributed to altered c-Myc expression.

The PARP (Poly(ADP-ribose) polymerase) protein is a zinc-dependant nuclear enzyme whose main role is to detect and repair DNA single-strand breaks (SSB). However, PARP antibody research has revealed there are at least 17 PARP proteins, which also play a major role in apoptosis (programmed cell death) and post-translational modification. We at Novus Biologicals have an extensive range of PARP antibody products in our antibody catalogu.

The glyceraldehyde 3-phosphate dehydrogenase, or GAPDH enzyme plays an important role in the conversion of glucose for energy, catalyzing the sixth step of the glycolytic pathway. A common and widely expressed protein, GAPDH mRNA is often used as a standard in mRNA studies. GAPDH antibody products are also used as a loading control in Western blot assays. We at Novus Biologicals have 55 GAPDH antibody products on our antibody database.

Novus Biologicals is one of the leading antibody suppliers of high affinity human epitope tag reagents, such as the HA tag antibody. Widely used in Western blot, ELISA and Immunohistochemistry assays, they offer a useful and reliable method for detecting, analyzing and purifying proteins from a wide range of species.

Caspase 3 is a member of the cysteine-aspartic acid protease family and an important mediator of apoptosis. Caspase 3 antibody reagents have been used in cancer, Alzheimer's disease and stem cell research. A recent caspase 3 antibody ELISA study showed elevated levels of the p17 caspase 3 fragment were associated with myocardial infarction in humans.

We at Novus Biologicals have a large HIF-1 (Hypoxia Inducible Factor-1) antibody catalog, with twenty HIF-1 beta antibody products specifically targeted to the beta subunit of HIF-1, a heterodimer which is known to contribute to many human diseases arising from changes in oxygen homeostasis.

The notch proteins are single-pass membrane receptors controlling a highly conserved signalling pathway. In vertebrates, the notch family comprises four transmembrane receptors encoded by four individual genes (NOTCH1 - 4). We at Novus Biologicals are leading NOTCH antibody suppliers, with an extensive range of NOTCH antibody products.

Phosphatase and tensin homologue (PTEN) antibodies are important tools for cancer research. PTEN is an important tumor suppressor but, in mutated form, is also expressed in a high number of cancers. We at Novus Biologicals have a wide PTEN antibody database, with 50 antibodies, proteins and lysates to choose from.