Antibody database

Caveolin-1 (CAV1) belongs to the caveolin family of integral membrane proteins 21-24 kD in size. This family of proteins forms the structural component of the caveolar membrane in caveolae, which are the specialized domains in plasma membrane that sequester lipids and proteins.

NBS1 (Nijmegen breakage syndrome protein 1) is a component of the MRN complex (Mre11-Rad50-Nbs1) that plays important role in detecting DNA double strand breaks (DSBs) and triggering the downstream cascade. DSBs can be caused by ionizing radiation, chemotherapy drugs, metabolic ROS, replication errors, programmed enzymatic activities during meiosis/V(D)J recombination, etc.

xCT, encoded by the gene SLC7A11, is a member of the heterodimeric amino acid transporter family. Proteins within this family are linked to one another via a disulphide bond to form heterodimers consisting of one light subunit and one heavy subunit (1). These heterodimers facilitate the transport of amino acids across cell membranes. The light subunit xCT dimerises with the heavy subunit 4F2hc and the role of the xCT-4F2hc heterodimer, also known as system Xc-, is to couple the release of one molecule of intracellular glutamate to the uptake of one molecule of extracellular cystine (2).

The DYKDDDDK Epitope Tag antibody was raised against a short, artificial sequence that is widely and commonly used as a protein fusion tag. It is pervasively present in a vast amount of scientific studies, and is a very powerful investigative research tool for applications such as immunofluorescence, immunoprecipitation, Western blot, and immunohistochemistry.

Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.

Learn more about Survivin in our infographic below.

Novus Biologicals offers various Survivin reagents for your research needs including:

The cytoskeleton consists of three major types of cytosolic fibers: microtubules, microfilaments (actin filaments), and intermediate filaments. Tubulins are the microtubule building block and exist as globular dimeric proteins of alpha/beta chains. There are five distinct forms: alpha, beta, gamma, delta, and epsilon tubulin.

Autophagy is a conserved mechanism whereby cells form double membrane autophagosomes to sequester cytoplasmic components for subsequent destruction by fusion with lysosomes (eukaryotes) or vacuoles (yeast). Targets of autophagy include aging proteins, damaged organelles and invasive pathogens, and the resulting breakdown products can be recycled back to the cytoplasm for re-use under conditions of starvation (1).

ZEB1 (Zinc finger E-box-binding homeobox 1) encodes a zinc finger transcription factor that represses T-lymphocyte-specific IL2-gene expression through binding to a small negative regulatory domain within the IL2 transcriptional start site (1).

TLR4 (Toll-like receptor 4) is a member of the Toll-like receptor (TLR) family that plays a key role in pathogen recognition and activation of innate immunity. Scientists have found that TLRs are highly conserved from Drosophila to humans, with a high degree of structural and functional homology.

Parkinson's disease is a degenerative disorder of the central nervous system, which involves the loss of dopaminergic neurons in the brain and gives rise to tremors, rigidity and slowness of movement. In the majority of cases there is no known cause; however mutations in a number of specific genes have been implicated.