Species: Hu, Mu, Rt, Pm
Applications: WB, Func, ICC/IF, IHC, IP, KD
Host: Mouse Monoclonal
Species: Hu, Mu, Ha
Applications: WB, Simple Western, ICC/IF, IP, ICC/IF (-)
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, Simple Western, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: AC
Description
Rad50 is a 153kDa protein that associates with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, the complex translocates to the nucleus of damaged cells, binds DNA, and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. Overall, Rad50 is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
10111 |
| Alternate Names |
- DNA repair protein RAD50
- EC 3.6
- EC 3.6.1.15
- EC 3.6.3
- EC 3.6.3.27
- hRAD50
- hRad50
- NBSLD
- RAD50 (S. cerevisiae) homolog
- RAD50 homolog (S. cerevisiae)
- RAD502
- RAD50-2
|
Related Rad50 Blog Posts
Check out the latest blog posts on Rad50.
The MRE11 Complex and DNA Damage Response
The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra... Read more.
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RAD50 and DNA Damage Response
DNA repair protein RAD50 is a component of the MRN complex (Mre11-RAD50-Nbs1) responsible for DNA double strand break (DSB) repair. DSBs are caused by ionizing radiation, certain chemotherapy drugs, metabolic reactive oxygen species (ROS), replication... Read more.
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Read more Rad50 related blogs.
