xCT antibodies

xCT: The Membrane's Gatekeeper

xCT is an obligate, electroneutral, membrane-bound anionic transporter responsible for regulating particular amino acid gradients via their transport through plasma membrane. The antiporter xCT superficially resembles an ion channel and preferentially catalyzes the exchange of L-cystine for L-glutamate residues in animal cells. Unlike other glutamate transporters like EAATs, xCT functions independently of an electrochemical sodium ion gradient. xCT is present in most peripheral tissues (heart, bone, liver, and testes).

xCT: Amino Acid Transport and Disorders of the Central Nervous System

xCT, encoded by the gene SLC7A11, is a member of the heterodimeric amino acid transporter family. Proteins within this family are linked to one another via a disulphide bond to form heterodimers consisting of one light subunit and one heavy subunit (1). These heterodimers facilitate the transport of amino acids across cell membranes. The light subunit xCT dimerises with the heavy subunit 4F2hc and the role of the xCT-4F2hc heterodimer, also known as system Xc-, is to couple the release of one molecule of intracellular glutamate to the uptake of one molecule of extracellular cystine (2).