Antibody database

We at Novus Biologicals are one of the leading antibody suppliers for products targeted to apoptosis. These products are regularly used by cancer research groups - apoptosis is fundamental to developing therapies that will kill tumor cells. Caspase proteins, which play a key role in apoptosis, are therefore regularly featured in our antibody catalog.

We at Novus Biologicals recently added two new MCP1 antibodies to our antibody catalog. MCP1, also known as MCAF (monocyte chemotactic and activating factor) is released by a diverse range of cell types as part of the inflammatory response. A member of the SIG (small inducible gene) family, it is selective for monocytes and basophils, mainly to recruit monocytes to injury and infection sites.

Supplying antibodies for neuroscience research forms an important part of our work here at Novus Biologicals. Our antibody database is represented by more than 5,600 neuroscience products covering conditions ranging from sensory systems to neurodegeneration.

Novus Biologicals is excited to announce the release of a new line of Antibody Purification Kits, for use with our popular Lightning Link Antibody Labeling Kits. These new kits allow researchers to label any antibody, regardless of the buffer or concentration, using the quick and easy Lightning Link method.

Stem cell marker antibodies are used to identify and isolate stem cells in vitro. Whereas adult stem cells can only differentiate into one cell type, embryonic stem cells (ESCs) have the unique ability to differentiate into a large variety. Stem cells can be genetically manipulated into specific cell lines, and researchers have recently developed a promising new method of producing ESC-like cell lines from adult stem cells.

Enzyme antibodies are widely used in both apoptosis and cancer studies, as disruption of the proteins regulating apoptosis is known to lead to formation of tumor cells in certain cancers. We at Novus Biologicals are continually growing our enzyme antibody database offerings.

At Novus Biologicals, we have over 9,000 products on our transduction antibody database. Signal transducers are proteins that facilitate movement of signals, i.e. molecules that cause a reaction, from outside to inside the cell, where they cause changes to cellular function and activity in either the cytoplasm or the nucleus. Transduction pathways are usually activated by complex enzyme cascades, and new proteins are constantly being developed. Thus, our antibody catalogue is constantly being updated.

Embryonic stem cells (ESCs) and their corresponding marker antibodies are often used in cancer research, since cell-renewal is a feature shared by both ESCs and cancer cells. The drawback is that there is no clear evidence of a transcription program common to both cell types. However, in a study (Wong et al. 2008), it was described how comparison of human and murine ESC-like gene modules had isolated a catalog of 335 genes, which could be used as a "core ESC-like gene module" for tumor studies.

Phosphospecific antibodies, such as our c-Fos, FANCD and Survivin (phos) antibody, target the phosphorylation sites of specific proteins. We at Novus Biologicals have many hundreds of phosphor-Abs, and are constantly expanding our antibody database. Phosphospecific Abs allows analysis of key targets in cancer, cardiovascular disease, diabetes etc.

A growing number of studies are looking at causes of cancer at a molecular level – and discovering that hypoxia pathways play a major role. This is because HIF (Hypoxia Inducible Factor) proteins work to prevent cell death. Combined with DNA-repair pathways and the apoptosis mechanism, it’s obvious what disruption of these pathways could lead to.