A large number of antibody assays are devoted to the study of nuclear excision repair (NER) proteins. However, there are a number of other DNA repair pathways, many of which are instigated by NER and share the same proteins. DNA repair antibodies are widely used in cancer research, and Novus Biologicals offers an extensive selection of thoroughly validated, high-quality DNA repair and cancer related antibodies.
Our antibody database at Novus Biologicals provides research tools for the forefront of cancer research. Recently, a mouse study using 53BP1 and BRCA1 antibodies showed that deletion of 53BP1 greatly lessened the incidence of tumor development in mice carrying the mutated BRCA1 gene.
PCNA antibodies are useful biomarkers in DNA repair studies. PCNA is one of several proteins essential for the completion of nucleotide excision repair, a multi-stage process involving 20 - 30 proteins, and an important factor in repairing damage and mutations to the DNA helical structure.
We at Novus Biologicals have over 230 products in our antibody catalog devoted to nucleotide excision repair. NER is a multi-stage sequential process involving over 30 proteins, all of which have been widely studied. Being the primary method to repair DNA damage caused by agents ranging from UV radiation to chemotherapy drugs, our NER antibody database is widely used by cancer research groups.
The mammalian DNA repair process encompasses a large number of protein pathways, and forms an important part of our antibody catalog. The past 30 years have seen tremendous advances in the understanding of these mechanisms, with Wood, et al. recently compiling an updated inventory of at least 150 human DNA-repair proteins. This added considerably to the scope of the antibody database of us at Novus Biologicals.
The typical way of detecting proteins by immunohistochemical staining involves a two-step process. A primary antibody is raised against the antigen, and then a second, fluorescently-labeled antibody is used to detect the first.
Dr. Randall Nelson and his Molecular Biomarkers Lab Team are the topic of this week's Novus Customer Focus. At Arizona State University's Biodesign Institute, Dr. Nelson and his lab conduct biomarker research to investigate and understand how biomarkers function and how they can be used in medical applications.
Novus Biologicals recently added a new PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene.
Veterinary research is a well established and growing field for studying animal reproduction, infectious disease, cancer and more. Research of vet species often requires the production and use of vet antibodies. Novus Biologicals provides an extensive line of antibodies for veterinary research. Novus' vet antibody line includes antibodies against many vet species, including bovine, canine, chicken, equine, feline, goat, porcine and sheep.
