The Adiponectin Antibody: Obesity, Diabetes and Breast Cancer Research

Fri, 06/17/2011 - 07:44

Adiponectin (also called ADIPOQ) is a cytokine expressed exclusively in adipose tissue. It has a number of functions, regulating lipid metabolism, gluconeogenesis and the inflammatory response. Adiponectin antibody products are widely used in diabetes, obesity and lipid metabolism research. Obesity and Type 2 Diabetes are linked to an increased risk of breast cancer in women. New adiponectin antibodies recently proved important in this area of research.

Immunocytochemistry: Adiponectin Antibody

Adiponectin levels are inversely related to adiposity and development of Type 2 Diabetes. Adiponectin antibody research has also revealed a strong link between ADIPOQ expression and breast cancer risk, with decreased blood serum levels linked to increased risk of breast cancer in obese patients, and vice versa. Adiponectin antibody studies have also suggested the protein may regulate TNF, IGF and oestrogen secretion.

Adiponectin binds to several receptors, including ADIPOR1 and ADIPOR2. In 2003 Miyoshi, Funahashi et al showed ADIPOR1/R2 expression in certain breast cancer cell lines, although proliferation was reduced when cells were exposed to ADIPOQ. Further studies revealed ADIPOQ and ADIPOR1 single nucleotide polymorphisms (SNPs) could affect expression of the protein, and were associated with increased risk of insulin resistance, diabetes mellitus and cardiovascular disease.

In 2008, V. Kaklamani et al examined the role of these SNPs in breast cancer development, in a case control study involving both breast cancer patients and healthy volunteers. Genotyped haplotype-tagging methods revealed a strong correlation between raised ADIPOQ/R1 SNP levels and increased breast cancer risk.

Novus Biologicals offers many Adiponectin reagents for your research needs including:


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