CXCL12/SDF-1 Products

Description

The C-X-C or alpha chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell-derived factor-1, or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes, but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven-pass, transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (also designated LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major co-receptor for T-tropic HIV-1, and SDF-1 has been shown to inhibit HIV-1 infection. Six human SDF-1 isoforms exist due to alternative splicing of CXCL12, the gene encoding SDF-1. Three isoforms are known for mouse and rat.

Bioinformatics

Entrez	20315 Mouse 493806 Feline 6387 Human
Uniprot	AAH39893 Human AAH39893.1 Human NM_199168 Human NP_000600 Human O62657 Feline P40224 Mouse P48061 Human P48061-1 Human Q6ICW0 Human
Product By Gene ID	6387
Alternate Names	chemokine (C-X-C motif) ligand 12 C-X-C motif chemokine 12 hIRH hSDF-1 Intercrine reduced in hepatomas IRH PBSFSDF-1a Pre-B cell growth-stimulating factor SCYB12 SDF-1 SDF1A SDF1B SDF1SDF-1b stromal cell-derived factor 1 TLSF TLSF-a TLSF-b TPAR1

Research Areas for CXCL12/SDF-1

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neuronal Cell Markers