SLC24A2 Antibody

Product Discontinued

SLC24A2 Antibody Summary

• Immunogen: Synthetic Peptide: D(90) L N D K I R D Y T P Q P(102)
• Localization: Plasma membrane
• Specificity: Detects rat sodium / calcium - potassium exchanger (NCKX 2) overexpressed in HEK cells transfected with the rat gene.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC24A2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Frozen 1:100
  • Immunohistochemistry-Paraffin 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot 1:100
• Application Notes: IP usage reported in scientific literature (PMID: 12377762), ICC/IF usage reported in scientific literature (PMID: 12377762).

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 12377762).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for SLC24A2 Antibody

• retinal cone Na-Ca+K exchanger
• solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Background

Sodium/calcium-potassium exchanger proteins (NCKX1) have been reported to occur in retinal photoreceptors and in brain (NCKX2). Unlike the abundant and widely expressed sodium/calcium exchanger which catalyzes the exchange of 3 sodium ions for 1 calcium ion to modulate intracellular calcium levels, NCKX isoforms exchange 4 sodium ions for 1 calcium and 1 potassium ion. The sodium/calcium-potassium exchanger uses the transmembrane sodium gradient to catalyze countertransport of calcium in a potassium-dependent mechanism against its electrochemical gradient. It is hypothesized that NCKX2 plays a significant role in calcium homeostasis and the regulation of neuronal function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC24A2
• Entrez:
  • 84550(Rat)