Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Description
Sodium/calcium-potassium exchanger proteins (NCKX1) have been reported to occur in retinal photoreceptors and in brain (NCKX2). Unlike the abundant and widely expressed sodium/calcium exchanger which catalyzes the exchange of 3 sodium ions for 1 calcium ion to modulate intracellular calcium levels, NCKX isoforms exchange 4 sodium ions for 1 calcium and 1 potassium ion. The sodium/calcium-potassium exchanger uses the transmembrane sodium gradient to catalyze countertransport of calcium in a potassium-dependent mechanism against its electrochemical gradient. It is hypothesized that NCKX2 plays a significant role in calcium homeostasis and the regulation of neuronal function.
Bioinformatics
| Entrez |
Human
Rat
|
| Product By Gene ID |
25769 |
| Alternate Names |
- retinal cone Na-Ca+K exchanger
- solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
|
