RGS20 Antibody Pack

Product Discontinued

RGS20 Antibody Pack Summary

• Immunogen: The following antibodies are included in this RGS20 antibody bundle: Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 148-161 Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 1-15 Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 30-48 Antibody to RGS20; Format: Rabbit sera; Application: ELISA; Immunogen: amino acids 171-189
• Host: Rabbit
• Gene: RGS20
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:100-1:2000

Reactivity Notes

Human and predicted to react with Mouse and Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Purity: Unpurified

Alternate Names for RGS20 Antibody Pack

• G(z)GAP
• Gz-GAP
• Gz-selective GTPase-activating protein
• regulator of G-protein signaling 20
• Regulator of G-protein signaling Z1
• regulator of G-protein signalling 20
• Regulator of Gz-selective protein signaling 1
• RGSZ1g(z)GAP
• ZGAP1gz-GAP

Background

RGS proteins are regulatory and structural components GPCR complexes. These are GAPs for Gi and Gq class Galpha proteins and negatively regulate GPCR signaling pathways. RGS20, a 25KDa protein, is a member of this family and is human homolog of bovine Gz-GAP. It contains an N-terminal cysteine string that is potential site for multiple palmitoylation and a C-terminal RGS core domain. RGS20 plays a vital role in regulating GPCR signals in brain, neuronal development and regulation of golgi structure. RGS20 specifically interacts and accelerates the hydrolysis of G-alphaz. Reports suggest that RGS20 interacts with G-alphai subunit and plays a significant role in regulation of G-alphai-mediated signaling. It is a membrane-bound protein specifically expressed in brain, with highest concentrations in caudate nucleus and temporal lobe.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RGS20