Relaxin R1/LGR7 Antibody (933344) [Unconjugated]


Relaxin R1 was detected in immersion fixed frozen sections of mouse brain (medulla) using Mouse Anti-Human Relaxin R1 Monoclonal Antibody (Catalog # MAB8898) at 2 µg/mL overnight at 4 °C. Tissue was stained using the more
Western blot shows lysates of LNCaP human prostate cancer cell line, SH‑SY5Y human neuroblastoma cell line, human heart tissue, mouse heart tissue, and rat heart tissue. PVDF membrane was probed with 2 µg/mL of more
SH‑SY5Y human neuroblastoma cell line was stained with Mouse Anti-Human Relaxin R1 Monoclonal Antibody (Catalog # MAB8898, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready

Relaxin R1/LGR7 Antibody (933344) [Unconjugated] Summary

Chinese hamster ovary cell line CHO-derived recombinant human Relaxin R1
Accession # Q9HBX9
Detects human Relaxin R1 in direct ELISAs and detects human, mouse, and rat Relaxin R1 in Western blots.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 2 ug/mL
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
  • CyTOF-ready

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Relaxin R1/LGR7 Antibody (933344) [Unconjugated]

  • leucine-rich repeat-containing G protein-coupled receptor 7
  • Leucine-rich repeat-containing G-protein coupled receptor 7
  • LGR7
  • LGR7.1
  • LGR7.10
  • LGR7LGR7.2
  • MGC138347
  • MGC142177
  • Relaxin family peptide receptor 1
  • Relaxin R1
  • relaxin receptor 1
  • relaxin/insulin-like family peptide receptor 1
  • RelaxinR1
  • RXFP1
  • RXFPR1


Relaxin R1 (Relaxin Receptor 1), also known as RXFP1 (Relaxin Family Peptide Receptor 1) or LGR7 (Leucine‑rich G‑protein‑coupled Receptor 7) is a member of family C of the LGRs, and is one of four receptors for Relaxin family proteins. Relaxin R1 shows highest affinity for human Relaxins 1, 2 and 3, while RXFP2 binds Relaxin 2 and the related INSL3, and RXFP3 primarily binds Relaxin 3 (1, 2). The 757 amino acid (aa) human Relaxin R1 contains an N‑terminal 409 aa extracellular domain (ECD) with a calcium‑binding LDL R class A (LDLa) domain and 10 leucine‑rich repeats (LRR) with several N‑glycosylation sites. The C‑terminus contains 12 transmembrane domains within aa 410‑672. Human Relaxin R1 (aa 1‑398) shares 84, 86, 85, 85 and 91% aa sequence identity with mouse, rat, equine, bovine and porcine Relaxin R1, respectively. Isoforms of 724 and 709 aa lack aa 63‑96 and 300‑348, respectively, while isoforms of 176, 189, 191 and 337 aa diverge after aa 154, 179, 181 and 324, respectively (3, 4). These forms may dimerize with full‑length Relaxin R1 and reduce its expression on the cell surface (3, 4). Receptor activation and cAMP signaling depend on the LDLa domain, and Relaxin binding requires the LRR repeats, with a secondary binding site within transmembrane region exoloops (1, 2, 5). Of LGR family members, RXFP1 and RXFP2 are unique in that they are not internalized to down‑regulate signaling, and their LDLa domains allow transmission of both G‑protein‑dependent and ‑independent signals (1, 2, 6, 7). Engagement of Relaxin R1 by Relaxin (mainly Relaxin 2 in humans) supports female reproduction by promoting uterine angiogenesis, ovarian follicle ripening, and endometrial, cervical and nipple development (8‑10). In male reproduction, Relaxin R1 acts in the prostate to enhance sperm motility (11). It reduces fibrosis in the heart, skin, lungs, liver, kidney, and reproductive tissues by combating aberrant collagen buildup (12). In the vasculature, it mediates vasodilation and decreases blood pressure. Relaxin R1 is expressed on human leukocytes and promotes adhesion, migration, and osteoclast differentiation (13, 14). Additional effects on heart, lungs, kidney and brain are reported, some of which may be species‑specific (1).

  1. van der Westhuizen, E.T. et al. (2008) Drug Discov. Today 13:640.
  2. Kong, R.C.K. et al. (2010) Mol. Cell. Endocrinol. 320:1.
  3. Muda, M. et al. (2005) Mol. Hum. Reprod. 11:591.
  4. Kern, A. et al. (2008) Endocrinology 149:1227.
  5. Hopkins, E.J. et al. (2007) J. Biol. Chem. 282:4172.
  6. Kern, A. and G.D. Bryant-Greenwood (2009) Endocrinology 150:2419.
  7. Halls, M.L. (2012) Br. J. Pharmacol. 165:1644.
  8. Kamat, A.A. et al. (2004) Endocrinology 145:4712.
  9. Krajnc-Franken, M.A. et al. (2004) Mol. Cell. Biol. 24:687.
  10. Yao, L. et al. (2008) Endocrinology 149:2072.
  11. Ferlin, A. et al. (2012) J. Androl. 33:474.
  12. Hossain, M.A. (2011) Biochemistry 50:1368.
  13. Ferlin, A. et al. (2010) Bone 46:504.
  14. Figueiredo, K.A. et al. (2006) J. Biol. Chem. 281:3030.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt, Eq
Applications: WB, IHC, IHC-P
Species: Hu, Rt, Ha
Applications: IHC, IHC-P
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P
Species: Hu
Applications: Flow, CyTOF-ready, ICC
Species: Hu
Applications: IHC-P
Species: Hu, Mk
Applications: IHC-P, ICC
Species: Hu
Applications: ICC/IF (-), WB, IHC, IHC-P
Species: Hu
Species: Hu, Mu, Rt, Bt, Bv, Ca, Eq, Ha, Mk, Pm
Applications: IHC-P
Species: Hu
Species: Hu, Mk
Applications: IHC-P
Species: Hu, Mu
Applications: WB, Flow, CyTOF-ready, ICC
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC-Fr, IHC-P, IP, PAGE
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, CyTOF-ready

Publications for Relaxin R1/LGR7 Antibody (MAB8898) (0)

There are no publications for Relaxin R1/LGR7 Antibody (MAB8898).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Relaxin R1/LGR7 Antibody (MAB8898) (0)

There are no reviews for Relaxin R1/LGR7 Antibody (MAB8898). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Relaxin R1/LGR7 Antibody (MAB8898) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional Array Products

Bioinformatics Tool for Relaxin R1/LGR7 Antibody (MAB8898)

Discover related pathways, diseases and genes to Relaxin R1/LGR7 Antibody (MAB8898). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Relaxin R1/LGR7 Antibody (MAB8898)

Discover more about diseases related to Relaxin R1/LGR7 Antibody (MAB8898).

Pathways for Relaxin R1/LGR7 Antibody (MAB8898)

View related products by pathway.

PTMs for Relaxin R1/LGR7 Antibody (MAB8898)

Learn more about PTMs related to Relaxin R1/LGR7 Antibody (MAB8898).

Blogs on Relaxin R1/LGR7

There are no specific blogs for Relaxin R1/LGR7, but you can read our latest blog posts.

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Relaxin R1/LGR7 Antibody (933344) [Unconjugated] and receive a gift card or discount.


Gene Symbol RXFP1